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Integrated Analysis using Metadata Framework and Correlation Analysis in GeneSpring 13 - Glioblastoma case study

Presented by Agilent Technologies and Strand Life Sciences

Abstract

Agilent Technologies GeneSpring® offers an intuitive and interactive environment for integrated analysis of transcriptomics, metabolomics, proteomics and NGS data within a biological context. This ability is now further enhanced by introduction of metadata framework and correlation analysis in GeneSpring 13.

Metadata analysis framework allows researchers to visualize the abundance profiles of samples alongside metadata such as clinical, physiological, or technology related information. Ideal for large datasets, metadata framework enables users to reveal tacit dependencies between characteristics of the subjects or samples and their gene, metabolite, or protein expression profiles. Correlation, on the other hand, is a statistical technique and measures the strength and directionality of linear relationship between two quantitative variables.

In this webinar, using the expression values, copy number and associated metadata for 173 Glioblastoma Multiforme (GBM) samples from TCGA, we will highlight and demonstrate the metadata framework and correlation functionality of GeneSpring. Specifically, we will focus on:

  • Identification of molecular subtypes in tumor samples using clustering and correlation analysis
  • Relationship between molecular subtypes and copy number aberrations using metadata analysis framework
  • Correlation analysis between mRNA and micro-RNA expression

    • Webinar Details



    Sessions San Francisco Time
    (PDT)    		 Tokyo Time
    (GMT+09:00)    		 Berlin Time
    (GMT+01:00)    		 Mumbai Time
    (GMT+05:30)
    Session 1
    SAPK/APFO    		 31 Mar
    9:00 PM    		 1 Apr
    1:00 PM    		 1 Apr
    6:00 AM    		 1 Apr
    9:30 AM
    Session 2
    EMEA    		 1 Apr
    7:00 AM     		1 Apr
    11:00 PM    		 1 Apr
    4:00 PM    		 1 Apr
    7:30 PM
    Session 3
    AFO    		 2 Apr
    9:00 AM     		3 Apr
    1:00 AM    		 2 Apr
    6:00 PM    		 2 Apr
    9:30 PM

    About Speakers

    Dr. Durairaj Renu, Senior Applications Scientist, Strand Life Sciences has a Ph.D. in Structural Biology from Indian Institute of Technology Roorkee. His expertise is in the field of bioinformatics, chemometrics, software development process and technical support. At Strand, Durai is working on GeneSpring, the multi-omics data analysis software and drives the functional validation of the application.

    Dr. Carolina Livi, has research experience in the fields of bioinformatics, regulatory biology, cancer and aging. Carolina Livi, has a Ph.D. in Molecular Developmental Biology, from the California Institute of Technology. Prior to joining Agilent, Dr. Livi worked at the University of Texas Health Science Center at San Antonio (UTHSCSA) as a Research Assistant Professor, in the department of Molecular Medicine. At Agilent, Dr. Livi is Bioinformatics Segment Manager for Life Sciences Research in Academia and Government within the Segment Marketing group.


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    Email: informatics_support@agilent.com
Phone (Japan): +81 42 660 9921
Phone (Worldwide): 1-800-227-9770

    Thank You

    Agilent Technologies and Strand Life Sciences Team



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